Personalized medicine is given a new perspective by bioengineering, and more specifically, tissue engineering. As already occurs with blood transfusions, bone marrow transplants, and autologous chondrocyte implantation to re-grow cartilage, the use of cells and treatments has become a powerful procedure to get the body to heal itself.Learn more by visiting orthopedic specialists near me
These techniques have paved the way for over 2000 clinical trials related to cell therapies, such as stem cells for ischaemic heart regions, Parkinson’s disease neural precursor cells, and oligodendrocytes from embryonic stem cells to treat spinal cord injuries.
Detecting the best pathway to move these cells is the key to success. Cell-based therapy is used to treat osteoarthritis of the knee, where cartilage and subchondral bone damage results in less fibro cartilage repair than the mechanical properties of articular cartilage. About 250,000 knee replacements are performed per year, with the majority of patients contracting acute degenerative joint disease. Since the cells have a propensity to form fibro cartilage and lose their round shape, injecting a suspension of autologous cultured chondrocytes into the problem area will not be efficient. The easiest way to treat osteoarthritis of the knee is to embed chondrocytes in the cartilaginous matrix, which wears away like cartilage.
When chondrocytes are encased in gels, their rounded shape is retained, and the properties of the gels can be managed to enable tissue regeneration. In order to hold up the cells, the mesh needs to be small enough and open enough to get water and nutrients. Similarly, at the correct rate, the gel structure must disintegrate so that the extracellular matrix secreted is not confined only to the region surrounding each chondrocyte.